Dec 7, 2018 · Older AEDs, acting on cytochrome P450 isoenzymes, and especially on CYP3A4, such as phenobarbital, phenytoin, and carbamazepine are more likely to significantly reduce the anticoagulant effect of DOACs (especially rivaroxaban, apixaban, and edoxaban)
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Carbamazepine, phenytoin, phenobarbital and primidone induce many cytochrome P450 (CYP) and glucuronyl transferase (GT) enzymes, and can reduce
The CYP3A subfamily is involved in many clinically significant drug
Phenytoin is extensively metabolized and is first transformed into a reactive arene oxide intermediate
The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing the phase 1 metabolism of pharmaceuticals and other xenobiotics
Recent findings about individual isoforms of the cytochromes P450 involved in the metabolism of phenytoin (PHT) and carbamazepine (CBZ) make prediction of inhibition
Cytochrome P450 (CYP450) are a group of enzymes encoded by the P450 genes and responsible for the metabolism of most drugs seen in clinical
Inhibition of one or both CYP2C19 and CYP3A isoforms is the likely mechanism by which INH slows the elimination of coadministered drugs, including phenytoin, carbamazepine
According to the manufacturer, quetiapine is primarily metabolized by CYP3A4
1994; 8 (Suppl 1):33–38
However, these Cytochrome P450 2C9: CYP2C9*3 (C;C) / (A;C) C Allele: Effect Directly Studied: Patients with this genotype have reduced metabolism of phenytoin
phenytoin 3A4 strong inducer Phenytoin (Dilantin) also decreases serum hormone levels and allows breakthrough bleeding
There is evidence for the teratogenicity of phenytoin in humans ingesting 100–800 mg per day during the first trimester of gestation
1 Divalproex is an enzyme inhibitor sometimes implicated in psychotropic drug-drug interactions
Human leukocyte antigen (HLA) alleles are well-known genetic predictors of certain antiepileptic drug
15,54 Drug Interactions: Mirtazapine has minimal inhibitory effects on CYP-1A2, CYP-2D6, and CYP-3A4
For the other CYP enzymes tested, no significant effects were observed
Interactions between DPH and tacrolimus suggested that the persistence of CYP induction after discontinuation of DPH is dependent on the history of administration and dosing period of DPH
, rifampin, phenytoin, phenobarbital) decrease the bioavailability and increase the clearance of verapamil and diltiazem